It works more slowly and lasts for about 12 hours, so you only need to take it once a day. http://www.upandaway.org. Consult your doctor for more details. The narrowing makes it more difficult for blood to flow to your heart muscle. What conditions does Isosorbide Mononitrate treat? It works and leaves the body quickly, so it needs to be taken twice a day. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing. tell your doctor and pharmacist if you are allergic to isosorbide; nitroglycerin tablets, patches, or ointment; any other medications, or any of the ingredients in isosorbide tablets, extended-release tablets, or extended-release capsules. https://naturalmedicines.therapeuticresearch.com. It can make you really dizzy. In: Current Medical Diagnosis & Treatment 2022. Do not double the dose to catch up. GoodRx works to make its website accessible to all, including those with disabilities. Yet significantly fewer patients had headache on low dosage than on high dosage (45 vs 57, P < 0.02). Whenever you take more than one medicine, or mix it with certain foods or beverages, you"re at risk of a drug interaction. Some brands of isosorbide mononitrate tablets should be taken two or three times a day. Cleophas TJ, Niemeyer MG, Zwinderman AH, van der Wall EE. This form of skin cancer is mostly caused by PhD (Pharmacology) Pursuing, M.Pharma (Pharmacology), B.Pharma - Certificate in Nutrition and Child Care, MBBS, Master in Healthcare Administration, Diploma in Occupational Health, What are the uses of Isosorbide Mononitrate. The table below contains some of the most common ones associated with isosorbide mononitrate. (3) The overall number of headache attacks in the first period of active treatment was significantly higher than in the second period irrespective of the dosages given. There may be variations in CSA schedules between individual states. Older adults may be more sensitive to the side effects of this medication, especially dizziness and lightheadedness, which could increase the risk of falls. If you have ever had an allergic reaction to a medicine. This medication is sometimes prescribed for other uses; ask your doctor or pharmacist for more information. In: Textbook of Natural Medicine. This is called a medicine interaction. Medicines containing Isosorbide Mononitrate. Does isosorbide mononitrate (Monoket) lower blood pressure? Natural Medicines. Isosorbide mononitrate belongs to the group of medicines called nitrates. Real test is coronary angiography. Includes Isosorbide Mononitrate indications, dosage/administration, pharmacology, mechanism/onset/duration of action, half-life, dosage forms, interactions, warnings, adverse reactions, off-label uses and more. Isosorbide extended-release (long-acting) tablets and extended-release capsules are used for the management of chest pain in people who have coronary artery disease. Does Viagra add to the risks of melanoma? Change positions slowly until your body is used to the medication. 55 ratings on Drugs.com. Alcohol will increase the risk of you experiencing side-effects such as feeling dizzy and light-headed. Isosorbide mononitrate has an average rating of Tachjian A, et al. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Headache and weakness of left side (both arm and leg) may suggest a brain pathology. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. This should pass after a few days. Natural Medicines. Anti-ischemic and anti-anginal effects of controlled-release and conventional isosorbide-5-mononitrate in stable angina pectoris. Methods: In a randomized, double-blind, crossover study, 89 patients with stable angina pectoris were studied to compare two different dosage strategies of isosorbide-5-mononitrate (5-ISMN). Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Of the total drug interactions, Isosorbide mononitrate (Monoket) is available as both a immediate-release (IR, short-acting) and extended-release (ER, long-acting) tablet. It also relaxes and widens blood vessels in your heart (coronary arteries) which increases the flow of blood to your heart muscle. 2021 May 11;39:28. doi: 10.11604/pamj.2021.39.28.22180. Although not all of these side effects may occur, if they do occur they may need medical attention.Check with your doctor immediately if any of the following side effects occur:Less commonAbnormal heart soundabsence of or decrease in body movementarm, back, or jaw painblack, tarry stoolsbladder painbleeding after defecationbleeding gumsblood in the urine or stoolsblurred visionbody aches or painburning while urinatingburning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelingschest pain or discomfortchest tightness or heavinesschillscold sweatscoldsconfusionconvulsionscough or hoarsenessdecreased urinediarrheadifficult or labored breathingdifficult, burning, or painful urinationdilated neck veinsdizzinessdizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting positiondry mouthear congestionextra heartbeatsfaintingfast, slow, irregular, pounding, or racing heartbeat or pulsefever or chillsflu-like symptomsfrequent urge to urinatefrequent urinationgeneral feeling of discomfort or illnessheadacheheadache, severe and throbbingheart murmurincreased need to urinateincreased sweatingincreased thirstincreased volume of pale, dilute urineirregular breathingitching, pain, redness, or swelling on the legjoint pain, stiffness, or swellinglightheadednessloss of appetiteloss of voicelower back, side, or stomach painmuscle aches and painsmuscle crampsnasal congestionnausea or vomitingnervousnessnumbness or tingling in the hands, feet, or lipspain or discomfort in the arms, jaw, back, or neckpain, tension, and weakness upon walking that subsides during periods of restpartial or slight paralysispassing urine more oftenpinpoint red or purple spots on the skinpounding in the earsrunny noseshakiness in the legs, arms, hands, or feetshiveringsneezingsore on the legsore throatsudden decrease in the amount of urinesweatingswellingswelling of the face, fingers, feet, or lower legstightness in the chesttrembling or shaking of the hands or feettrouble sleepingtroubled breathinguncomfortable swelling around the anusunusual bleeding or bruisingunusual tiredness or weaknessvomiting of blood or material that looks like coffee groundsweaknessweight gainRareBluish-colored lips, fingernails, or palmsdark urinepale skinrapid heart rateGet emergency help immediately if any of the following symptoms of overdose occur:Symptoms of overdoseBlurred or loss of visionbulging soft spot on the head of an infantchange in consciousnesschange in the ability to see colors, especially blue or yellowcold, clammy skindisturbed color perceptiondouble visionfeeling of constant movement of self or surroundingshalos around lightsheadache, severe and throbbingloss of consciousnessnight blindnessoverbright appearance of lightsparalysissensation of spinningtunnel visionSome side effects may occur that usually do not need medical attention. flushing - try to cut down on coffee, tea and alcohol because they can make flushing worse. Check out these best-sellers and special offers on books and newsletters from Mayo Clinic Press. Glyceryl trinitrate (GTN) is commonly prescribed for this. There are 195 drugs known to interact with The extended-release tablet usually is taken once daily in the morning. 8600 Rockville Pike Let your provider know if you are using any medications for erectile dysfunction before you start taking isosorbide mononitrate (Monoket). The .gov means its official. Headaches can be a sign that the medicine is working, and they might lessen with continued use of the medication. Drug interactions may change how your medications work or increase your risk for serious side effects. In a randomized, double-blind, crossover study, 89 patients with stable angina pectoris were studied to compare two different dosage strategies of isosorbide-5-mononitrate (5-ISMN). 67% of reviewers reported a positive effect, while 13% reported a negative effect. Am J Ther. Avoid combinations; the risk of the interaction outweighs the benefit. 41% of reviewers reported a positive effect, while 50% reported a negative effect. https://naturalmedicines.therapeuticresearch.com. Any use of this site constitutes your agreement to the Terms and Conditions and Privacy Policy linked below. What is the difference between the immediate-release (IR) and extended-release (ER) versions of isosorbide mononitrate (Monoket)? If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088). Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Once- versus twice-daily administration of controlled-release isosorbide-5-mononitrate 60 mg in the treatment of stable angina pectoris. This drug may make you dizzy. Our clinical information meets the standards set by the NHS in their Standard for Creating Health Content guidance. Garlic. For even more savings, use a GoodRx coupon and pay just a fraction of the retail price. Take them to your local pharmacy which will dispose of them for you. Herbal supplements can interact with medicines used to treat heart and blood vessel problems, such as high blood pressure and heart failure. Isosorbide may cause other side effects. This is called tolerance, and it cannot be fixed by raising the dose of the medication. Your body can get used to isosorbide mononitrate (Monoket), and the same amount of medication might no longer work as well as it used to. If you have an eye condition called glaucoma. Angina pain develops if part of your heart muscle does not get as much blood and oxygen as it needs. In the remainder of them there was a highly significant time effect: the overall numbers of headache attacks in the first period of active treatment versus the second were 2,380 vs 1,400 (P < 0.003). A randomized, double-blind, cross-over study. information submitted for this request. sharing sensitive information, make sure youre on a federal Higher dosages are associated with stomach irritation and Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. This site complies with the HONcode standard for trustworthy health information: verify here. Longer-acting tablets and capsules are taken once daily in the morning. Some conditions may become worse when the drug is suddenly stopped. Background: Nitrates, although important for the management of angina pectoris, cause significant headache in many patients. Isosorbide mononitrate should not be used in patients with severe anaemia, severe hypotension, closed angle glaucoma or severe hypovolaemia.Isosorbide mononitrate may give rise to postural hypotension and syncope in some patients. Fish Oil (omega-3 polyunsaturated fatty acids), Email this report to a friend, doctor, or patient, isosorbide mononitrate consumer information. Isosorbide can only be used to prevent angina; it cannot be used to treat an episode of angina once it has begun. Herbal supplements and heart medicines may not mix, Your blood pressure, if you also take a drug to treat high blood pressure, Beta blockers, such as atenolol (Tenormin), nadolol (Corgard) or propranolol (Inderal LA, Innopran XL), Calcium channel blockers, such as diltiazem, nifedipine (Procardia) and verapamil (Calan SR, Verelan), Nitrates, such as nitroglycerin (Nitrostat, Nitro-Dur, others) and isosorbide (Isordil, Bidil), Statins, such as atorvastatin (Lipitor), lovastatin (Altoprev) and rosuvastatin (Crestor), Anti-rejection medicine, also called immunosuppressant medicine, such as cyclosporine (Gengraf, Neoral, Sandimmune). Yes, it's good for health but don't take it excesse in amount, use once daily for 1 month then stop it or take once a weekly. Review/update the Mehta D. Herbal & dietary supplements. This list covers only some interactions. This is not a complete list of possible side effects. The information on this page is written and peer reviewed by qualified clinicians. Do not drink alcohol while taking View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions. It is not suitable to take to treat an angina attack - you should always carry with you a short-acting nitrate, such as glyceryl trinitrate (GTN), for if you get angina pain. . Data were assessed for carryover and time effects. If you have an underactive thyroid gland. If you are taking other medicines, including those available to buy without a prescription, as well as herbal or complementary medicines. coma (loss of consciousness for a period of time). May also be prescribed off label for Esophageal Spasm. All rights reserved. daily and increasing to 40 mg three times daily as necessary, given at 8 AM, 1 PM, and 6 PM), isosorbide mononitrate (starting at 30 mg/day in the morning and increasing to 120 mg/day as necessary), or a transdermal. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API). If concomitant therapy cannot be avoided, monitor clinical effects of the . Do not stop taking isosorbide without talking to your doctor. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs (including any herbal medicines or supplements) or following any treatment or regimen. Treatment and prognosis of heart failure with preserved ejection . However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Natural Medicines. St. John's wort. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. Patient does not provide medical advice, diagnosis or treatment. [2] It is taken by mouth. Erectile dysfunction medications (e.g., sildenafil (Viagra), vardenafil (Levitra), tadalafil (Cialis)) cannot be taken while you're taking isosorbide mononitrate (Monoket). Herbal supplements can interact with medicines used to treat heart and blood vessel problems, such as high blood pressure and heart failure. Do not store in the bathroom. Is not subject to the Controlled Substances Act. (1) Starting on a low dosage was associated with a reduced frequency and severity of headache and did not notably influence the beneficial effect on angina pectoris. If tolerance is suspected during the use of transdermal patches they should be left off for 8-12 hours (usually overnight) in each 24 hours; in the case of modified-release tablets of isosorbide dinitrate (and . This medicine is available only with your doctor's prescription. In case of overdose, call the poison control helpline at 1-800-222-1222. This product is available in the following dosage forms: There is a problem with Accessed Sept. 7, 2022. Who should not take Isosorbide Mononitrate? Hawthorn. Theyre fast, easy-to-use and free! It has a very short duration of action and may not be suitable for some people. tell your doctor if you are taking or have recently taken riociguat (Adempas) or a phosphodiesterase inhibitor (PDE-5) such as avanafil (Stendra), sildenafil (Revatio, Viagra), tadalafil (Adcirca, Cialis), and vardenafil (Levitra, Staxyn). Keep all medicines out of the reach and sight of children. Breastfeeding:There is data that nitrates are excreted in breast milk and may cause methemoglobinemia in infants. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Elsevier; 2021. https://www.clinicalkey.com. tell your doctor if you may be dehydrated, if you have recently had a heart attack, or if you have or have ever had heart failure, low blood pressure, or hypertrophic cardiomyopathy (thickening of the heart muscles). Herbal supplements can strongly affect the body. We study millions of patients and 5,000 more each day. There are no data on passage of isosorbide mononitrate in human milk, but some excretion seems likely. Natural remedies for depression: Are they effective? It does not work fast enough to relieve the pain of an angina attack that has already started. Alternative drugs to the conditions Isosorbide mononitrate treats: Angina High blood pressure Stable angina Chest pain Heart disease Heart attack Angina unstable Heart disease congenital Coronary heart disease Heart failure Pulse Heart rate irregular Coronary artery spasm Angioplasty National Library of Medicine Your doctor may decide not to treat you with this medication or change some of the other medicines you take. Many herbal supplements can interact with prescription drugs. Vascular dilatation can precipitate venous pooling with decreased return to the heart, hypotension and reflex tachycardia. Accessed Sept. 7, 2022. Some side effects may occur that usually do not need medical attention. This information is aggregated and used to produce personalized reports that patients can reference. Do not use medications containing isosorbide dinitrate while using isosorbide mononitrate. If you do not remember until your next dose is nearly due, then leave out the forgotten dose and take your next dose when it is due. See also: aspirin side effects in more detail. Overview of herbal medicines and dietary supplements. Saw palmetto might make your risk of bleeding higher if you also take a blood thinner, such as: It's not suggested to take St. John's wort if you take blood thinners. Some of these medicine interactions can be risky. It took me a few weeks to adapt to it, but the effect on preventing chest pain was dramatic. the unsubscribe link in the e-mail. Do not stop taking it without consulting your doctor. A total of 195 drugs are known to interact with isosorbide mononitrate: A total of 330 drugs are known to interact with aspirin: A total of 239 drugs are known to interact with nitroglycerin: No known alcohol/food interactions. Also, it is not intended to be taken just before physical activities (such as exercise or sexual intercourse) to prevent chest pain. Do not flush medications down the toilet or pour them into a drain unless instructed to do so. 2023 eHealthMe.com. Information is for End User's use only and may not be sold, redistributed or otherwise used for commercial purposes. What side effects can this medication cause? Some of these medicine interactions can be risky. MBBS, MS - General Surgery, mch neuro surgery. This medication performs a vasodilatory function and is therefore used as a treatment for high blood pressure. Tolerance is more likely to happen if you don't take your dose at the same time every day. B12 and folic acid is essential along with iron. 1994 Jan;15(1):108-13. doi: 10.1093/oxfordjournals.eurheartj.a060361. Mayo Clinic offers appointments in Arizona, Florida and Minnesota and at Mayo Clinic Health System locations. (2) One in 3 patients never experienced headache from the given dosages. It can cause your blood pressure to become dangerously low. The site is secure. Dehydration in Buspar, how severe and when it was recovered? Valerian: A safe and effective herbal sleep aid? We study 23,548 Isosorbide mononitrate users. . 72% of reviewers reported a positive effect, while 12% reported a negative effect. isosorbide mononitrate, along with 8.0 out of 10 from a total of Mayo Clinic Graduate School of Biomedical Sciences, Mayo Clinic School of Continuous Professional Development, Mayo Clinic School of Graduate Medical Education, Alternative cancer treatments: 11 options to consider. Store it at room temperature and away from excess heat and moisture (not in the bathroom). Isosorbide comes as a tablet, an extended-release (long-acting) tablet, and an extended-release capsule to take by mouth. Isosorbide is a medication used to treat and prevent angina pectoris in patients with coronary heart disease. Taking erectile dysfunction medications or drinking alcohol while taking isosorbide mononitrate (Monoket) can cause your blood pressure to get dangerously low, which can be life-threatening. Heres what you need to know about alcohol and blood pressure including how alcohol can interact with your blood pressure medications. Be sure to follow your provider's instructions about when to take isosorbide mononitrate (Monoket). Keep this medication in the container it came in, tightly closed, and out of reach of children. information is beneficial, we may combine your email and website usage information with Can isosorbide mononitrate cause problems? It works by relaxing the blood vessels and increasing the supply of blood and oxygen to the heart while reducing its workload. Selected from data included with permission and copyrighted by First Databank, Inc. The drug donates nitric oxide to the body, which is similar to all other Isosorbide mononitrates. Herbal supplements are natural, so they must be safe, right? This site needs JavaScript to work properly. You will find a full list in the manufacturer's information leaflet supplied with your medicine. It works by relaxing the blood vessels and increasing the supply of blood and oxygen to the heart while reducing its workload. If this worries you, talk to your doctor or pharmacist about other options. The American Society of Health-System Pharmacists, 4500 East-West Highway, Suite 900, Bethesda, Maryland. Please enable it to take advantage of the complete set of features! What should I know about storage and disposal of this medication? Isosorbide mononitrate Aspirin Prescription only Prescribed for Angina Pectoris Prophylaxis, Heart Failure. As precautionary measure, breast-feeding should be discontinued during treatment with isosorbide mononitrate. Mayo Clinic on Incontinence - Mayo Clinic Press, NEW The Essential Diabetes Book - Mayo Clinic Press, NEW Ending the Opioid Crisis - Mayo Clinic Press, FREE Mayo Clinic Diet Assessment - Mayo Clinic Press, Mayo Clinic Health Letter - FREE book - Mayo Clinic Press. Sildenafil ( Viagra ), tadalafil ( Cialis ), avanafil ( Stendra ),and vardenafil ( Levitra) increase the blood pressure lowering effects of isosorbide mononitrate and may cause excessive reductions in blood pressure. Isosorbide mononitrate, sold under many brand names, is a medication used for heart-related chest pain ( angina ), heart failure and esophageal spasms. Read our editorial policy. It is used to treat and prevent a wide range of different conditions. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. Important information about all medicines, Notes on Isosorbide mononitrate dose and side-effects info, https://patient.info/medicine/isosorbide-mononitrate-elantan-imdur-isotard-monomax-tardisc-xismox, Manufacturer's PIL, Isosorbide mononitrate 10 mg tablets, Carmil XL; Chemydur XL; Elantan LA; Imdur; Isib XL; Ismo; Isodur XL; Isotard XL; Modisal XL; Monomax SR; Monomil XL; Nyzamac SR; Relosorb XL; Tardisc XL; Trangina XL; Xismox XL; Zemon XL, Tablets, modified-release (longer-acting) tablets, and modified-release (longer-acting) capsules, Ask your doctor or pharmacist to recommend a suitable painkiller. Lyrica and Metoclopramide drug interaction, Calcitriol and Metoclopramide drug interaction. Mayo Clinic; 2021. https://naturalmedicines.therapeuticresearch.com. I strongly feel that there is coronary ischemia. Do not share this medication with others. information highlighted below and resubmit the form. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: continuing ringing or buzzing or other unexplained noise in the ears, dull ache or feeling of pressure or heaviness in the legs, excess air or gas in the stomach or intestines, increased sensitivity of the eyes to sunlight, loss in sexual ability, desire, drive, or performance, pain or tenderness around the eyes and cheekbones, redness of the face, neck, arms, and occasionally, upper chest, redness, pain, swelling of the eye, eyelid, or inner lining of the eyelid, redness, swelling, or soreness of the tongue, small clicking, bubbling, or rattling sounds in the lung when listening with a stethoscope, stomach bloating, burning, cramping, or pain, terrifying dreams causing sleep disturbances, uncontrolled twisting movements of the neck, white patches in the mouth, tongue, or throat.